Biotechnological Equipment
Advanced search
Article
Biotechnology & Biotechnological Equipment 27 (6), 4308 - 4310 (2013)
http://dx.doi.org/10.5504/BBEQ.2013.0093
PHARMACEUTICAL BIOTECHNOLOGY
CYTOTOXICITY OF MONENSIC ACID AND ITS BIOMETAL(II) COMPLEXES AGAINST ANAEROBIC BACTERIAL STRAIN CLOSTRIDIUM PERFRINGENS SPP.
Rumyana Zhorova1, Maya Marina2, Antoaneta Radeva2, Mariana Mitewa3, Ivayla Pantcheva3
- GE Pharmaceuticals Ltd., Botevgrad, Bulgaria
- National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
- Sofia University “St. Kliment Ohridski”, Faculty of Chemistry and Pharmacy, Sofia, Bulgaria
Correspondence to: Rumyana Zhorova E-mail: ahrh@chem.uni-sofia.bg; Ivayla Pantcheva E-mail: ahip@chem.uni-sofia.bg
Published 18 December 2013
Abstract
The cytotoxic properties of Monensic acid (MonH) and its biometal(II) complexes [M(Mon)2(H2O)2] (M = Mg, Ca, Mn, Co, Ni, Zn) against the Gram-positive anaerobic bacterium Clostridium perfringens spp. are reported. All the studied Monensin complexes possess similar structures, but their activity varies in the concentration range from 0.17 μmol/L to 11.90 μmol/L. Biometal(II) complexes improved the properties of Monensic acid in in vitro experiments, suggesting their possible practical application as more effective antibacterial agents than the non-coordinated antibiotic.
Keywords
Monensin, biometal(II) complexes, C. perfringens
ADVERTISEMENT
ADVERTISEMENT
