Article

Certain evidence has been collected about the imperative role of chromatin remodeling complexes (CRCs) in the fine tuning of genome activity. One of the most abundant CRCs is INO80 which is evolutionary conserved from yeast to human. INO80 consists of several subunits, all of them playing important roles in its functioning. The actin-related protein -Arp4p, is one of these subunits. Although ARP4 gene is essential for the yeast cells certain arp4 mutants do exist, thus providing good opportunities for studying of INO80 roles in the higher-order building of chromatin. Using the advantages of S. cerevisiae we have traced the interaction between Аrp4p and linker histones.