Biotechnology & Biotechnological Equipment 21 (4), 393 - 398 (2007)
INFLUENCE OF VOLATILE ANAESTHETICS ON LUNG CELLS AND LUNG SURFACTANT
E. Stephanova1 , R. Valtcheva-Sarker1 , T. Topouzova-Hristova1 , Z. Lalchev2 Sofia University “St. Kliment Ohridski”, Faculty of Biology, Department of Cytology, Histology and Embryology, Sofia, Bulgaria Sofia University “St. Kliment Ohridski”, Faculty of Biology, Department of Biochemistry, Sofia, Bulgaria Correspondence to: Z. Lalchev E-mail: lalchev@biofac.uni-sofia.bg
Abstract Volatile anaesthetics as halothane, enflurane, isoflurane, sevoflurane and desfluane have significant role in surgery. Anaesthesia could affect breath holding and might cause a dose-dependent depression in respiration. Lung epithelial cells are the first barrier against inhaled agents. Among them the pneumocytes type II are the main producers of pulmonary surfactant. Damage of lung surfactant (LS) is one of the possible reasons for the respiratory complications. In contrast to studies, concerning the influence of general anaesthetics on lung surfactant functionality, there is still poor information about the influence, based on the alveolar cell cultures. In this review we focus our attention on the data indicating the harmful effect of anaesthetics and mainly of halothane on the properties of lung cells, biosynthesis, secretion and functionality of LS components, using an appropriate cell culture model system and we discuss as far as possible the mechanism underlying the halothane toxicity.
Hide ReferencesAvery M.E., Mcad J. (1959) AMA. J. Dis. Child., 97 , 517-523.Azuma K., Mike N., Fujiwara Y., Shimada Y., Watanabe T. (1993) J. Anesth., 7 , 442-446.Ben-Eliyahu S., Page G.G., Yirmiya R., Shakhar G. (1999) Int. J. Cancer, 80 , 880-888.Blanck T.J.J. (1999) Ital. J. Neurol. Sci., 20 , 431-435.Chang Y.C., Chou M.Y. (2001) J Endod., 27 (2), 82-84.ChangLai S.P., Hung W.T., Liao K.K. (1999) Respiration, 66 (6), 506-510.Craig N.C., Bryant G.J., Levin I.W. (1987) Biochemistry, 26 , 2449-2458.Della Rocca G., Costa M.G., Bruno K., Coccia C., Pompei L., DiMarco P., Pretagostini R., Colonnello M., Rossi M., Pietropaoli P., Cortesini R. (2001) Pediatr. Surg. Int., 17 (2-3), 175-179. Dzoljic M., Bene L., Krasznai Z., Damjanovich S., Van Duijn B. (2000) J. Photochem. Photobiol. B, 56 (1), 48-52.Enhorning G., Pototschnik R., Possmayer F., Burgoyne R. (1986) Anesth. Analg., 65 (12), 1275-1280. Franks N.P., Lieb W.R. (1994) Nature, 367 , 607-614.Gulfo N., Bartucci R., Sportelli L. (1988) Z. Naturforsch., 43 , 264.Gunaydin B., Karadenizli Y., Babacan A., Kaya K., Unlu M., Inanir S., Mahli A., Akcabay M., Yardim S. (1997) Respir. Med., 91 (6), 351-360.Häcker G. (2000) Cell Tiss. Res., 301 , 5-17.Hawgood S., Clements J. (1990) J. Clin. Invest., 86 , 1-6. Hill M. (1978) Ann. NY Acad. Sci., 101-110.Hoet P., Graf M.-L., Bourdi M., Pohl L.R., Duray P.H., Chen W., Peter R., Nelson S.D., Verlinden N., Lison D. (1997) Lancet, 350 , 556-559.Itoh T., Namba T., Fukuda K., Semenza G.L., Hirota K. (2001) FEBS Lett., 509 (2), 225-229.Jarstrand C. (1984) In: Pulmonary Surfactant (Robertson, B., Van Golde, L. M. G., Batenburg, J. J. Eds.), Elsevier Science Publishers, Amsterdam, Chap. 6.Johnson S.M., Bangham A.D. (1969) Biochim. Biophys. Acta 193 , 92-104.Kehlet H. (1997) Br. J. Anaesth., 78 , 606-617.King R.J., Clements J.A. (1972) Am. J. Physiol., 223 , 715-726.Kitteringham N.R., Kenna J.G., Park B.K. (1995) Br. J. Clin. Pharmacol., 40 , 379-386.Kleinsasser A., Lindner K.H., Hoermann C., Schaefer A., Keller C., Loeckinger A. (2001) Anesthesiology, 95 (6), 1422-1426.Koehler L.S., Fossel E.T., Koehler K.A. (1977) Biochemistry, 16 , 3700-3705Kudoh A., Matsuki A. (2000) Anesth. Analg., 91 (2), 440-445.Lalchev Z., Christova Y., Todorov R., Alexandrov V., Stoichev P., Petkov R. (1992) App. Cardiopulm. Pathophys. , 4 , 315-322.Li J., Marsh J.J., Spragg R.G. (2002) Am. J. Respir. Cell Mol. Biol., 26 (6), 709-715.Lieber M., Smith B., Szakal A., Nelson-Rees W., Rodaro G. (1976) Int. J. Cancer, 17 (1): 62-70.Lopez M.M., Kosk-Koicka D. (1995) J. Biol. Chem. 270 (47), 28239-28245.Lu Q., Harrington E.O., Rounds S. (2005) Keio J Med, 54 (4), 184-189.Macnaughtan W., Macdonald A.G. (1980) Biochim. Biophys. Acta, 597 , 193-198.Mobert J., Zahler S., Becker B.F., Conzen P.F. (1999) Anesthesiology, 90 , 1372-1381.Molliex S., Crestani B., Dureuil B., Bastin J., Rolland C., Aubier M., Desmonts J.M. (1994) Anesthesiology, 81 (3), 668-676.O’Keeffe . (1999) Pharmacol. Therap., 84 , 233-248.Park K.W., Dai H.B., Lowenstein E., Sellke F.W. (1998) Anasth. Analg., 86 (3), 646-651.Pattle R. (1955) Nature, 175 , 1125-1126. Paugam-Burtz C., Molliex S., Lardeux B., Rolland C., Aubier M., Desmonts J.M., Crestani B. (2000) Anesthesiology, 93 (3), 805-810.Pohl L., Kenna J, Satoh H., Christ D., Martin J. (1989) Drug Metab. Rev., 20 , 203-217.Porter A.G. (1999) Trends in Cell Biology, 9 , 394-401.Rithalia A., Qureshi M.A., Howarth F.C., Harrison S.M. (2004) Brit. J. Anaesth., 92 (2), 246-253.Roch A., Shlyonsky V., Goolaerts A., Mies F., Sariban-Sohraby S. (2006) Mol. Pharmacol., 69 (5), 1755-1762.Rudolph A.J., Smith C.A. (1960) J. Pediatr., 57 , 907-911.Salo M. (1992) Acta Anasthesiol. Scand., 36 , 201-220.Sanders R.L. (1982) In: Lung development: Biological and Clinical Perspectives (Farrel P.M., Ed.), vol. 1, Academic Press, New York Simon S., McIntosh T., Bennett P., Shrvastav B. 1987; Mol. Pharamcol., 16 , 163-170.Smuszkiewicz P., Drobnik L., Mieszkowski J., Konikowski A., Hołyñska I., Kaczorowski P., Tyrakowski T. (2006) Pharmacol. Reports, 58 , 736-745.Stanley T.H., Zikria B.A., Sullivan S.F. (1972) Aneshtesiology, 37 , 445-449.Stimson L.M., Vattulainen I., Ryg T., Karttunen M. (2005) Cell. Mol. Biol. Lett., 10 , 563-569.Suezaki Y., Shabata A., Kamaya H., Ueda I. (1985) Biochim. Biophys. Acta, 817 , 139-146.Tobin R.W., Kaiser HE, Groeger, A.M., Lema M.J. (2000) In vivo, 14 , 157-164.Tonnesen E. (1989) Dan. Med. Bull., 36 , 263-281Topouzova T., Moreno F.J., Daza P., Stephanova E. (2003) Ann. Univ. Sofia, 95 , 53-58.Topouzova-Hristova T., Daza P., Herdugo G., Stephanova E. (2006) Toxicol. in vitro, 20(5) , 585-593.Topouzova-Hristova T., Hazarosova R. Bandreva B., Stephanova E. (2007) Folia Biologica (Praha) 53 , 176-182.Trudell J.R., Bertaccini E. (2002) British J. Anaesth., 89 (1), 32-40.Valtcheva, R., Stephanova, E., Jordanova, A., Pancov, R., Altankov, G. and Lalchev, Z. (2003) Chem. Biol. Interact., 146 , 191-200.Valtcheva-Sarker R., Stephanova E., Hristova K., Altankov G., Momchilova A., Pankov R. (2007) Mol. Cell. Biochem., 295 , 59-64.Wennberg A. (1980) J Endoodon., 6 , 784-787.Woo S.W., Berlin D., Hedley-White J. (1969) J Applied Physiology, 26 , 571-577.Wright J.R., Dobbs L.G. (1991) Ann. Rev. Physiol., 53 , 395-414. Yoshida T., Taga K., Okabayaashi H., Kamaya H., Ueda I. (1989) Biochim. Biophys. Acta, 984 , 253-256. Yu W.F., Yang L.Q., Zhou M.T., Liu Z.Q., Li Q. (2005) World J. Gastroent. 11 (32), 5025-5028.
